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Austin Mall YG-1 DH421 Boston Mall Carbide Dream Extra Long Bit Drill Str Finish TiAlN

YG-1 DH421 Carbide Dream Extra Long Drill Bit, TiAlN Finish, Str


YG-1 DH421 Carbide Dream Extra Long Drill Bit, TiAlN Finish, Str


Product description

Extra long length dream drill bits with coolant holes. Right hand spiral, 30 degree helix. 140 Degree point angle. Made of Carbide. Shank tolerance ød2: -0.0/-0.0005. 8xD. Application for drilling into steel in general, cast steel, cast iron, chilled cast iron, malleable cast iron, non-ferrous heavy metal, non-ferrous light metal, abrasive plastic. Advantage: Self centering (center drilling is not required); Excellent positioning (bush is not necessary) and Special Design (reaming is not required, good chip removal, powerful drilling).

YG-1 DH421 Carbide Dream Extra Long Drill Bit, TiAlN Finish, Str

September, 2021

No. 106 (9)

2020 Impact Factor: 9.941 Submission > Acceptance: 52 days
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Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma

This open-label, single-arm study investigated the long-term efficacy of tafasitamab plus lenalidomide in 81 patients with relapsed/refractory diffuse large B-cell lymphoma. The response rate was 57.5%, including complete responses in 40.0% of patients, and the median duration of response was 43.9 months. This treatment is a valuable option for patients not eligible for autologous stem-cell transplantation.

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CAMT-MPL: congenital amegakaryocytic thrombocytopenia caused by MPL mutations - heterogeneity of a monogenic disorder - a comprehensive analysis of 56 patients

The clinical picture of 56 patients with congenital amegakaryocytic thrombocytopenia due to MPL mutations was much more varied than previously thought. Twenty-five per cent of them had no signs of thrombocytopenia at birth, and 50% had non-hematologic defects. Pancytopenia developed in (nearly) all patients and hematopoietic stem-cell transplantation was effective in 87% of cases.

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Oxidative stress activates red cell adhesion to laminin in sickle cell disease

Sickle red blood cells exhibit abnormal adhesion to laminin mediated by Lu/BCAM protein at their surface. This study provides evidence of the involvement of oxidative stress in post-translational modifications of Lu/BCAM which impact the protein’s distribution and cis-interaction with glycophorin C at the cell surface activating its adhesive function in dense sickle red cells. The authors speculate that antioxidant drugs might attenuate this phenomenon.

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